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\n

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\"\"<\/figure>\n\n\n\n

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\u25cf \u5b50\u5bab\u9888\u764c<\/p>\n\n\n\n

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\u25cf \u5b50\u5bab\u5185\u819c\u764c<\/p>\n\n\n\n

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\u25cf \u5375\u5de2\u764c<\/p>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

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\n

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\"\"<\/figure>\n\n\n\n

\u4e0d\u540c\u5206\u671f\u7684\u6cbb\u7597\u65b9\u6848<\/h2>\n\n\n\n
\n

\u25cf \u5b50\u5bab\u9888\u764c<\/p>\n<\/div>\n\n\n\n

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\u2022 I \u671fA\u3001B1-2\uff1a\u624b\u672f\u6cbb\u7597<\/p>\n\n\n\n

\u2022 I \u671fB3 (\u80bf\u7624\u76f4\u5f84\u5927\u4e8e4\u516c\u5206)\uff1a\u653e\u5c04\u5316\u5b66\u6cbb\u7597\uff08\u5316\u7597\u5408\u5e76\u653e\u5c04\u6cbb\u7597\uff09<\/p>\n\n\n\n

\u2022 II \u671fA1(\u80bf\u7624\u76f4\u5f84\u5c0f\u4e8e4\u5398\u7c73\uff0c\u4e14\u5df2\u6269\u6563\u81f3\u9634\u9053)\uff1a\u53ef\u8003\u8651\u624b\u672f\u6cbb\u7597<\/p>\n\n\n\n

\u2022 II \u671fA2\u6216B\uff1a\u653e\u5c04\u5316\u5b66\u6cbb\u7597\uff0c\u4e0d\u9002\u5408\u624b\u672f\u6cbb\u7597<\/p>\n\n\n\n

\u2022 III\u3001IV \u671f\uff1a\u653e\u5c04\u5316\u5b66\u6cbb\u7597<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u25cf \u5b50\u5bab\u5185\u819c\u764c<\/p>\n\n\n\n

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\u25cf \u5375\u5de2\u764c<\/p>\n\n\n\n

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\"\"<\/figure>\n\n\n\n

\u6807\u9776\u5408\u5e76\u514d\u75ab\u6cbb\u7597\u534f\u52a9\u5ef6\u957f\u5b58\u6d3b\u671f<\/h2>\n\n\n\n

\u7814\u7a76\u53d1\u73b0\uff0c\u6807\u9776\u6cbb\u7597\u6216\u514d\u75ab\u6cbb\u7597\u5408\u5e76\u5316\u7597\uff0c\u6709\u52a9\u4e8e\u5ef6\u957f\u60a3\u8005\u7684\u65e0\u6076\u5316\u5b58\u6d3b\u671f(Progression-free Survival)\uff0c\u76f8\u5173\u836f\u7269\u4e3b\u8981\u5206\u4e3a\u4e09\u5927\u7c7b\uff1a<\/p>\n\n\n\n

    \n
  1. \u8840\u7ba1\u65b0\u751f\u6291\u5236\u5242\uff1a\u7528\u4e8e\u963b\u6b62\u80bf\u7624\u65b0\u751f\u8840\u7ba1\u5f62\u6210\uff0c\u8fdb\u800c\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u53ef\u5728\u8fdb\u884c\u5316\u7597\u671f\u95f4\u540c\u6b65\u4f7f\u7528\uff0c\u5e76\u5728\u5316\u7597\u7ed3\u675f\u540e\u7ee7\u7eed\u7ef4\u6301\u6cbb\u7597\uff0c\u6709\u52a9\u4e8e\u5ef6\u7f13\u5375\u5de2\u764c\u590d\u53d1\u65f6\u95f4\uff0c\u4e5f\u9002\u7528\u4e8e\u665a\u671f\u5b50\u5bab\u9888\u764c\u6216\u764c\u75c7\u590d\u53d1\u60a3\u8005\uff0c\u53ef\u5ef6\u957f\u6570\u6708\u5b58\u6d3b\u671f\u3002<\/li>\n\n\n\n
  2. PARP\u6291\u5236\u5242\uff1a\u80fd\u591f\u963b\u65ad\u764c\u7ec6\u80de\u5bf9\u53d7\u635fDNA\u7684\u4fee\u590d\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u4e34\u5e8a\u663e\u793a\u5bf9\u5375\u5de2\u764c\u6cbb\u7597\u6548\u679c\u663e\u8457\u3002\u82e5\u60a3\u8005\u63a5\u53d7\u94c2\u7c7b\u5316\u7597\u540e\u7597\u6548\u8f83\u597d\uff0c\u53e3\u670dPARP\u6291\u5236\u5242\u53ef\u5e2e\u52a9\u7ef4\u6301\u6cbb\u7597\u6548\u679c\u3002\u8be5\u836f\u7269\u8fd8\u80fd\u5e2e\u52a9BRCA\u57fa\u56e0\u7a81\u53d8\u5e26\u56e0\u8005\u5ef6\u7f13\u590d\u53d1\u7ea63\u5e74\uff0c\u5176\u4ed6\u60a3\u8005\u5219\u53ef\u5ef6\u7f13\u6570\u6708\u3002<\/li>\n\n\n\n
  3. \u514d\u75ab\u6cbb\u7597\u836f\u7269\uff1a\u5b58\u5728\u514d\u75ab\u53d7\u4f53\u5f02\u5e38\u6216\u9ad8\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027(Microsatellite Instability\uff0c\u7b80\u79f0MSI)\u7684\u60a3\u8005\uff0c\u53ef\u900f\u8fc7\u4f7f\u7528PDL1\u6291\u5236\u5242\u6062\u590d\u514d\u75ab\u7ec6\u80de\u6740\u4f24\u764c\u7ec6\u80de\u7684\u80fd\u529b\u3002<\/li>\n<\/ol>\n\n\n\n
    \"\"<\/figure>\n\n\n\n

    \u5b50\u5bab\u5185\u819c\u764c\u53ef\u80fd\u4e0e\u9057\u4f20\u6027\u57fa\u56e0\u6709\u5173\u3002\u6797\u5947\u75c7\u5019\u7fa4(Lynch Syndrome)\u662f\u4e00\u79cd\u4f53\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u75be\u75c5\uff0c\u60a3\u8005\u56e0\u643a\u5e26\u9519\u914d\u4fee\u590d\u57fa\u56e0(Mismatch Repair\uff0c\u7b80\u79f0MMR)\u7a81\u53d8\uff0c\u7f79\u60a3\u5b50\u5bab\u5185\u819c\u764c\u7684\u98ce\u9669\u9ad8\u8fbe40%-60%\uff0c\u8bf1\u53d1\u5375\u5de2\u764c\u7684\u98ce\u9669\u4e5f\u9ad8\u8fbe10%\u3002\u6b64\u7c7b\u5177\u6709\u9057\u4f20\u80cc\u666f\u7684\u60a3\u8005\u53ef\u8003\u8651\u4f7f\u7528\u514d\u75ab\u7597\u6cd5\u836f\u7269\u3002<\/p>\n\n\n\n

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    \u4fdd\u5b88\u6cbb\u7597\u4fdd\u7559\u751f\u80b2\u529f\u80fd<\/h2>\n\n\n\n

    \u989c\u5a49\u5ae6\u533b\u5e08\u8868\u793a\uff0c\u5b50\u5bab\u5207\u9664\u672f\u662f\u5927\u90e8\u5206\u5987\u79d1\u6076\u6027\u80bf\u7624\u7684\u5e38\u89c4\u6cbb\u7597\u65b9\u6848\uff0c\u4f46\u5bf9\u4e8e\u6709\u751f\u80b2\u610f\u613f\u4e14\u764c\u75c7\u5904\u4e8e\u65e9\u671f\u7684\u5e74\u8f7b\u60a3\u8005\uff0c\u63a5\u53d7\u4fdd\u5b88\u6cbb\u7597\u662f\u53e6\u4e00\u4e2a\u53ef\u884c\u9009\u62e9\uff1a<\/p>\n\n\n\n

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    \"\"<\/figure>\n\n\n\n

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    \"\"
    \u989c\u5a49\u5ae6\u533b\u751f
    \u517b\u548c\u533b\u9662\u5987\u79d1\u80bf\u7624\u79d1\u4e13\u79d1\u533b\u751f<\/figcaption><\/figure>\n\n\n\n

    <\/p>","protected":false},"excerpt":{"rendered":"

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